A peptide mimotope of type 8 pneumococcal capsular polysaccharide induces a protective immune response in mice.

Triple tandem mimotope peptide of Epidermal Growth Factor Receptor displaying on the surface of M13 phage induces anti-tumor response in mice tumor model

Introduction: Epidermal growth factor receptor (EGFR) has been shown to play a critical role in tumor cell growth and its overexpression has been observed in many epithelial tumors. In the field of cancer vaccine research, displaying the peptide mimotope on the surface of phage particles has shown promising results. Methods: In this study using m13-PVIII phage display system, two constructs we...

Use of Insertional Inactivation to Facilitate Studies of Biological Properties of Pneumococcal Surface Protein

Infants and very young children are poor responders to polysaccharide antigens (1-4) and fail to make protective antibody responses to a number of polysaccharide-containing vaccines including the 23-valent pneumococcal vaccine (2, 5) currently used to immunize adults (6). One way to attempt immunization of children against encapsulated bacteria is to modify the capsular polysaccharides so that ...

Dendritic cell-derived exosomes express a Streptococcus pneumoniae capsular polysaccharide type 14 cross-reactive antigen that induces protective immunoglobulin responses against pneumococcal infection in mice.

Exosomes activate T cells in vivo, but whether exosomes are able to induce humoral immune responses is still unknown. We found that dendritic cells, but not other immune cells, constitutively release an exosome-associated glycoconjugate that is cross-reactive with the capsular polysaccharide of Streptococcus pneumoniae type 14 (Cps14-CRA). Cps14-CRA was localized to the cholesterol-enriched mic...

Unrelated Antibodies Peptide Mimotope Can Bind to Two Capsular Polysaccharide of 6B Serotype: A Peptide Mimotopes of Pneumococcal

Protective humoral response against pneumococcal infection in mice elicited by recombinant bacille Calmette-Guerin vaccines expressing pneumococcal surface protein A

Pneumococcal surface protein A (PspA), a cell-surface protein present on all strains of pneumococci, has been shown to elicit protective antibody responses in mice in the absence of capsular polysaccharide. Whereas PspA is polymorphic, considerable cross-reactivity and cross-protection have been demonstrated among PspA proteins of pneumococci exhibiting different capsular and PspA serotypes. A ...